Self-assembling siloxane nanoparticles with three phases that increase tenacity of poly L-lactic acid
نویسندگان
چکیده
منابع مشابه
Self-Assembling Siloxane Nanoparticles with Three Phases
Inorganic nanometer-sized particles (nanoparticles) are attracting attention as reinforcing fillers for use in polymer-nanoparticle composites (nanocomposites) because they improve key characteristics of these composites at a relatively low content (Hussain et al., 2006, Jordan et al., 2005). For example, clay nanoparticles (Usuki et al, 2005), metal oxide nanoparticles such as silica (Rosso et...
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We report here on the synthesis and characterization of a series of self-assembling biomaterials with molecular features designed to interact with cells and scaffolds for tissue regeneration. The molecules of these materials contain cholesteryl moieties, which have universal affinity for cell membranes, and short chains of lactic acid, a common component of biodegradable tissue engineering matr...
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Poly(l-lactic acid)-based films which include 60 wt % of vaterite (V) or siloxane-containing vaterite (SiV) were coated on a pure magnesium substrate, denoted by PLLA/V or PLLA/SiV, respectively, to suppress early corrosion and improve its cytocompatibility. Both coating films adhered to the Mg substrate with 2.3-2.8 MPa of tensile bonding strength. Soaking test for 7 days in α-modified minimum...
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Targeted drug delivery requires novel biodegradable, specific binding systems with longer circulation time. The aim of this study was to prepare biotinylated poly(lactic acid) (PLA) nanoparticles (NPs) which can meet regular requirements as well conjugate more biotins in the polymer to provide better binding with streptavidin. A biotin-graft-PLA was synthesized based on previously published bio...
متن کاملTreatment of experimental arthritis with poly(D, L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate.
OBJECTIVE To examine the therapeutic activity of hydrophilic glucocorticoid encapsulated in PLGA nanoparticles, which have shown slow release and are targeted to inflamed joints after intravenous administration, in experimental arthritis models. METHODS Betamethasone sodium phosphate (BSP) encapsulated in PLGA nanoparticles with a size of 100-200 nm (PLGA-nanosteroid) was prepared using a mod...
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ژورنال
عنوان ژورنال: Polymer Journal
سال: 2010
ISSN: 0032-3896,1349-0540
DOI: 10.1038/pj.2010.107